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Bienvenue - Laboratoire Jacques-Louis Lions

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5 postes ATER en mathématiques à Sorbonne Université
date limite le 5 avril à 16h
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189 personnes travaillent au LJLL

90 permanents

82 chercheurs et enseignants-chercheurs permanents

8 ingénieurs, techniciens et personnels administratifs

99 personnels non permanents

73 doctorants

14 post-doc et ATER

12 émérites et collaborateurs bénévoles

 

Chiffres mars 2019

 

GdT Thésards : S. Eugène

Stochastic Modelling of Polymerisation of Proteins - Sarah Eugène

To investigate intrinsic or extrinsic variability among amyloid formation experiments, we propose and study a new stochastic model, which is able to capture the main mechanisms of fibrillization while keeping a relative simplicity, which allows us for quantitative analysis. At first order, a law of large numbers shows its convergence towards the deterministic law of mass action, whereas at second order we prove a central limit theorem, which provides a stochastic differential equation that we solve explicitely. We then compared our analytical results with experimental data obtained on β2-m formation, what leads us to modify the original model by the addition of a conformation step. This new model is able to explain intrinsic variability in amyloid formation not only for in vivo but also for in vitro experiments, and paves the way for a new and efficient methodology.