The role of protein-mRNA interactions to control expression and activity in the p53 pathway.
The p53 and the genotoxic response pathways is one of the best studied
molecular pathways for how a cell damaging event leads to a specific
cell biological response.
This has profound implications for understanding the development of
cancer and for therapeutic development but also for a more generic
understanding of basic mechanisms
and concepts for how the cell responds to stress. This pathway has also
been used to to bring cell biology from a strict inductive to
more a more deductive field of research.
There are however, a number of different factors playing in making this
task difficult. Here I will describe a relative novel concept in which
mRNAs play an important role in
controlling the expression and activity of their encoded products within the p53 pathway.