The role of protein-mRNA interactions to control expression and activity in the p53 pathway.

The p53 and the genotoxic response pathways is one of the best studied molecular pathways for how a cell damaging event leads to a specific cell biological response.
This has profound implications for understanding the development of cancer and for therapeutic development but also for a more generic understanding of basic mechanisms
and concepts for how the cell responds to stress. This pathway has also been used to to bring cell biology from a strict inductive  to more a more deductive field of research.
There are however, a number of different factors playing in making this task difficult. Here I will describe a relative novel concept in which mRNAs play an important role in
controlling the expression and activity of their encoded products within the p53 pathway.